CBD Relief Roll-on

CONSUMER MEDICINE INFORMATION

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As an Australian Hemp Company, our mission is to improve the lives of individuals and families globally, through providing access to high quality, therapeutic, plant-based cannabinoid products.

SEED-TO-SHELF QUALITY PROCESS:

Ananda Hemp controls the entire process of production from seed to shelf, which includes over 30+ quality check points to ensure quality and safety of all products for patients. Every batch is 3rd party tested for quality, potency, solvents. pesticides. microbials and heavy metals to provide full transparency to patients and their doctors.

ANANDA PRODUCT OVERVIEW

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POTENTIAL SIDE EFFECTS: Potential side effects of oral CBD include somnolence. diarrhoea, heartburn, sleep disturbances, dizziness, rash, dry mouth, and change in appetite. Frequency of side effects of cannabidiol is considered rare via topical delivery.

The white willow bark and the alpha hydroxy acid (AHA) in the roll-on may increase skin's sensitivity to the sun and particularly the possibility of sunburn. Use a sunscreen. wear protective clothing, and limit sun exposure while using this product.

WARNINGS: Possession without authority is illegal. Keep out of reach of children. Limited data exist regarding safety while using in pregnancy and breastfeeding. Discontinue use immediately if you develop evidence of an allergic reaction, such as a rash or irritation at application site.

These medications are not TGA registered medicines and Ananda Hemp is only available by authorised prescrib­ ers (APs) and Special Access Scheme pathway (SAS-B).

ANANDA PRODUCT OVERVIEW (CONT.)

HOW TO ADMINISTER AND USE CBD RELIEF ROLL-ON:

Shake well. Massage gently into clean, dry skin with roller ball. Apply as needed. For external use only. Avoid contact with eyes. Discontinue if irritation occurs.

Apply to affected area generously daily or as needed. Can apply multiple times per day. Topical administration of cannabidiol limits systemic absorption, metabolism, and elimination. For maximum benefits, the CBD Roll-on may be prescribed with Ananda Hemp Full or THC free broad spectrum oil or soft gels.

BACKGROUND EDUCATION

WHAT IS THE ENDOCANNABINOID SYSTEM (ECS)?

The Endocannabinoid System (ECS) is a network of receptors present throughout the central and peripheral nervous systems as well as on many organs and organ systems. Two main receptor types. CB1 and CB2, comprise the ECS. CB1 receptors are abundant in nervous tissue and are the most abundant in the brain. CB2 receptors are present in the brain, but are more localised throughout the periphery and particularly on immune and lymphatic cells. Through CB1 and CB2 receptors. the ECS infiuences balance or homeostatic function via multiple mechanisms of action, impacting immune responses, infiammation, appetite, metabolism, pain perception, muscle relaxation, mood, motor control & coordination and more. CB1 and CB2 receptor activity is modulated by anandamide and 2-arachidoniclycerol (2-AG). two confirmed endogenous ligands, as well as exogenous cannabinoids, such as CBD and THC.

The ECS performs critical roles in dermatological health, such as maintaining skin barrier function, reducing oxidative stress, protecting membrane integrity, and promoting homeostasis. CB1 and CB2 receptors are also present on dermal cells, cutaneous nerve fibers, epidermal keratinocytes and eccrine glands. Cannabinoids interact with these receptors as well as TRP receptors in fibroblasts, Langerhans, and sebaceous glands.

WHAT IS THE DIFFERENCE BETWEEN CBD AND THC?

Both CBD and THC are cannabinoids that naturally occur in cannabis plants. Cannabinoids are compounds that interact with and infiuence activity of the ECS. CBD, or cannabidiol, is a non-intoxicating cannabinoid. THC, or delta-9 tetrahydrocannabinol, is the primary psychoactive component responsible for the intoxicating effects elicited by some cannabis plants known as marijuana. Both CBD and THC have therapeutic targets, but CBD does not possess the risk of intoxication, dependency or withdrawal that may accompany THC.

THC is a partial agonist of CB1 receptors, the mechanism by which intoxicating or psychotropic effects of cannabis occur. CBD is a potents antagonist and negative allosteric modulator of CB1 receptors. therefore inhibiting at least some of the intoxicating effects of THC.

BACKGROUND EDUCATION (CONT.)

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WHY FULL SPECTRUM HEMP EXTRACT?

Full spectrum hemp extract consists of multiple phytocompounds, predominantly CBD, but with small amounds of naturally occurring THC and other minor cannabinoids. CBD is complimented by the presence of other cannabinoids, terpenes. and botanicals to contribute to the synergy known as the 'entourage effect'. The entourage effect refers to the improved therapeutic responses elicited when CBD is combined with other compounds versus on its own (CBD isolate).

Full Spectrum extract is shown to produce a therapeutic effect at lower doses than CBD isolate due to the entourage effect, therefore being safer and cheaper for patients.

WHY IS CBD USED TOPICALLY?

The endocannabinoid system influences a myriad of physiological functions. and therefore cannabinoids have multiple and varied therapeutic targets. CBD has been utilised as an anti-inflammatory, analgesic, anti-psychotic, anticonvulsant, anxiolytic, anti-insomnia, anti-nausea and neuroprotective agent. Topical CBD can be used to target various pain mechanisms and inflammatory dermatological conditions and eruptions. such as psoriasis, rheumatoid arthritis, eczema, atopic dermatitis, and pruritis.

CLINICAL TRIALS FOR ANANDA HEMP EXTRACT:

Ananda Hemp Extracts have been used in an open-label prospective study evaluating their effects on opioid use, chronic pain, and sleep quality among a single cohort of chronic pain patients.

ONGOING CLINICAL TRIALS INCLUDE THE EFFECTS OF ANANDA HEMP EXTRACT ON:
  • CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY AMONG BREAST, COLON, UTERINE, AND OVARIAN CANCER PATIENTS
  • AGITATION IN ALZHEIMER'S DEMENTIA PATIENTS
  • SLEEP DISTURBANCES
  • LESION PROLIFERATION AND INNERVATION ON WOMEN WITH ENDOMETRIOSIS

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